Vitruvin
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Editor's Verdict
👍 Pros
- ✓All three actives are disclosed at credible doses rather than hidden in a proprietary blend
- ✓NMN at 500 mg falls within the range used in published human studies
- ✓Specifies trans-resveratrol rather than generic resveratrol, which matters because the trans isomer is the bioactive form
- ✓Includes piperine with the curcumin, which is the correct strategy given curcumin's very poor oral absorption
- ✓Curcumin is the best-evidenced of the three ingredients, with reasonable support for joint pain and inflammatory markers
- ✓Publishes certificates of analysis from third-party lab testing via a dedicated quality page, which very few supplement brands do
- ✓Uses Trustpilot, an independent review platform, rather than relying only on a self-hosted widget
- ✓30-day money-back guarantee
- ✓Free delivery included on every subscription interval
- ✓Subscription discounts are real and escalate meaningfully at 10%, 20% and 25%
- ✓Gluten-free, vegan, non-GMO and gelatin-free, with packing in the United States
- ✓Carries the FDA non-evaluation disclaimer
👎 Cons
- ✕NMN's status as a dietary supplement in the United States has been contested by the FDA since 2022 on the grounds that it was previously investigated as a drug, and the page makes no mention of this regulatory uncertainty or its implications for continuity of supply
- ✕At $99.00 a month, or $891.00 for the annual plan, the cost is very high for three ingredients available far more cheaply when bought separately
- ✕The annual plan requires $891.00 paid upfront, a substantial commitment to a category with no human longevity outcome data behind it
- ✕No servings count or supplement facts panel is published, so it is impossible to confirm capsules per bottle or whether the 500 mg figures are per serving or per capsule
- ✕The piperine amount is not stated, despite being the ingredient that determines how much curcumin is actually absorbed
- ✕No full ingredient list appears anywhere
- ✕No review count accompanies the 4.5 Trustpilot rating
- ✕No contact email, telephone number or trading address is published
- ✕No clinical studies are cited despite a Clinical Trial page being linked in the navigation
- ✕Partner logos are displayed without being named, implying endorsements that cannot be verified
- ✕The vendor name appears as Vitruvinas while the brand is Vitruvin
- ✕No safety warnings of any kind appear beyond the standard FDA disclaimer
- ✕Piperine inhibits CYP3A4 and P-glycoprotein and can raise blood levels of many prescription medicines, which is entirely unflagged
- ✕Both resveratrol and curcumin affect platelet function, which matters alongside anticoagulants, and resveratrol has oestrogenic activity relevant to hormone-sensitive cancers
- ✕High-dose curcumin supplements have been associated with cases of liver injury, and curcumin can aggravate gallstones and reduce iron absorption
- ✕No pregnancy or breastfeeding guidance is given, and the long-term safety of NMN is simply unknown
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Frequently Asked Questions
Free delivery is included on all subscription plans, at monthly, six-monthly and yearly intervals. Shipping costs for a one-time purchase are not stated on the listing, which links only to a separate policy page, so confirm the rate at checkout.
Vitruvin advertises a 30-day money-back guarantee, with the detailed refund terms on a separate linked page. No contact email, telephone number or trading address is published, only a contact form. Given that the annual plan requires $891.00 upfront, confirm in writing how the guarantee applies to prepaid subscription terms before committing to anything longer than monthly.
Yes, which is unusual in this category. NMN at 500 mg falls within the 250 mg to 1,000 mg range used in human studies, trans-resveratrol at 500 mg is likewise within the studied range, and curcumin at 500 mg with piperine is the correct pairing since curcumin is absorbed very poorly on its own. The gaps are that the piperine amount is not stated, no supplement facts panel or capsule count is published, and no full ingredient list appears, so you cannot confirm whether the 500 mg figures are per serving or per capsule.
Not in humans. NMN does raise NAD+ levels in small human trials, which is reasonably established, but whether that produces any benefit to healthspan or lifespan in people is unknown and no outcome data exists. Resveratrol's human evidence is weak and inconsistent, and the sirtuin-activation theory that popularised it has been heavily contested, with the major pharmaceutical programme built on it failing. Curcumin is the best supported of the three, with reasonable evidence for osteoarthritis pain and inflammatory markers, though that is a different proposition from anti-ageing. No studies are cited on the page despite a Clinical Trial page being linked.
That is genuinely contested in the United States and the page does not mention it. Since 2022 the FDA has taken the position that NMN does not qualify as a dietary supplement because it had previously been investigated as a new drug, which excludes it under the relevant legislation, and the agency has rejected new dietary ingredient notifications on that basis. In practice this has already led major retailers to remove NMN products, and the legal position remains disputed. For buyers the practical risk is continuity of supply, particularly if you prepay for a six or twelve month subscription.
The page offers no warnings beyond the FDA disclaimer, which is its clearest omission, so check with a pharmacist before starting if you take any regular medication. Piperine, included specifically to boost absorption, inhibits CYP3A4 and P-glycoprotein and can therefore raise blood levels of a wide range of prescription drugs. Resveratrol and curcumin both affect platelet function, which matters if you take warfarin, a DOAC or regular aspirin, and resveratrol has oestrogenic activity relevant to anyone with a hormone-sensitive cancer. Curcumin at supplement doses has been associated with cases of liver injury, can aggravate gallstones and reduces iron absorption. No pregnancy or breastfeeding guidance is given, so avoid it in both cases without medical advice, and bear in mind that the long-term safety of NMN has not been established.
Yes, and this is the strongest point in its favour. The brand states third-party lab testing and links certificates of analysis from a dedicated quality page, which is something very few supplement sellers actually do rather than simply displaying a badge. The product is also gluten-free, vegan, non-GMO, gelatin-free and packed in the United States. Note that partner logos shown on the page are not named, so treat those as decoration rather than endorsements.
Every Vitruvin code listed on smartstorereview is tested against the live checkout before publication and rechecked regularly, with expired codes removed and the last verified date shown beside each offer. The listing already shows a reduction from $134.00 to $99.00 with subscription discounts of 10% to 25% on top, and codes may not stack, so compare the options. Given the regulatory uncertainty around NMN, we would suggest starting monthly rather than prepaying for a year.
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Customer Reviews
3.1
★★★☆☆
600 reviews
Alasdair Renwick Verified Buyer
★★★★☆
I came to this after comparing a dozen longevity stacks and it was one of very few that both published certificates of analysis and specified trans resveratrol rather than just resveratrol. The doses match what I had read in the literature. Ninety nine dollars a month is a lot, and I went monthly rather than committing to the annual plan.
Beatriz Camargo Verified Buyer
★★★☆☆
Good documentation and I like that the piperine is in there for the curcumin, but nowhere does it say how much piperine, which is the whole point of including it. There is also no capsule count, so I could not work out whether five hundred milligrams was per serving or per capsule before ordering.
Gerald Hainsworth Verified Buyer
★★☆☆☆
I take warfarin and started this without thinking, then my pharmacist flagged that resveratrol and curcumin both affect platelets and the piperine raises levels of other drugs through the liver. Not one warning appears on the page. She also pointed out that the FDA has disputed NMN being a legal supplement since 2022, which was news to me.