Vitruvin

Vitruvin

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★★★★☆ 4.7 (2,345 reviews)

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Editor's Verdict

👍 Pros

  • ✓All three actives are disclosed at credible doses rather than hidden in a proprietary blend
  • ✓NMN at 500 mg falls within the range used in published human studies
  • ✓Specifies trans-resveratrol rather than generic resveratrol, which matters because the trans isomer is the bioactive form
  • ✓Includes piperine with the curcumin, which is the correct strategy given curcumin's very poor oral absorption
  • ✓Curcumin is the best-evidenced of the three ingredients, with reasonable support for joint pain and inflammatory markers
  • ✓Publishes certificates of analysis from third-party lab testing via a dedicated quality page, which very few supplement brands do
  • ✓Uses Trustpilot, an independent review platform, rather than relying only on a self-hosted widget
  • ✓30-day money-back guarantee
  • ✓Free delivery included on every subscription interval
  • ✓Subscription discounts are real and escalate meaningfully at 10%, 20% and 25%
  • ✓Gluten-free, vegan, non-GMO and gelatin-free, with packing in the United States
  • ✓Carries the FDA non-evaluation disclaimer

👎 Cons

  • ✕NMN's status as a dietary supplement in the United States has been contested by the FDA since 2022 on the grounds that it was previously investigated as a drug, and the page makes no mention of this regulatory uncertainty or its implications for continuity of supply
  • ✕At $99.00 a month, or $891.00 for the annual plan, the cost is very high for three ingredients available far more cheaply when bought separately
  • ✕The annual plan requires $891.00 paid upfront, a substantial commitment to a category with no human longevity outcome data behind it
  • ✕No servings count or supplement facts panel is published, so it is impossible to confirm capsules per bottle or whether the 500 mg figures are per serving or per capsule
  • ✕The piperine amount is not stated, despite being the ingredient that determines how much curcumin is actually absorbed
  • ✕No full ingredient list appears anywhere
  • ✕No review count accompanies the 4.5 Trustpilot rating
  • ✕No contact email, telephone number or trading address is published
  • ✕No clinical studies are cited despite a Clinical Trial page being linked in the navigation
  • ✕Partner logos are displayed without being named, implying endorsements that cannot be verified
  • ✕The vendor name appears as Vitruvinas while the brand is Vitruvin
  • ✕No safety warnings of any kind appear beyond the standard FDA disclaimer
  • ✕Piperine inhibits CYP3A4 and P-glycoprotein and can raise blood levels of many prescription medicines, which is entirely unflagged
  • ✕Both resveratrol and curcumin affect platelet function, which matters alongside anticoagulants, and resveratrol has oestrogenic activity relevant to hormone-sensitive cancers
  • ✕High-dose curcumin supplements have been associated with cases of liver injury, and curcumin can aggravate gallstones and reduce iron absorption
  • ✕No pregnancy or breastfeeding guidance is given, and the long-term safety of NMN is simply unknown
Our verdict: Vitruvin does the technical basics properly, which deserves recognition after a long run of products that do not. All three actives are disclosed at doses that match the published research, the resveratrol is specified as the trans isomer rather than left ambiguous, piperine is included precisely because curcumin is almost unabsorbable without it, and the brand publishes actual certificates of analysis from third-party testing rather than displaying a badge and hoping nobody asks. Using Trustpilot rather than a self-hosted review widget is another point in its favour. Two things should temper enthusiasm. The first is evidence: NMN does raise NAD+ levels in humans, but whether that produces any healthspan or longevity benefit is entirely unestablished, resveratrol's human evidence is weak and the sirtuin story that made it famous has been substantially contested, and curcumin, the best-supported of the three, is supported for joint pain rather than ageing. Paying $891 a year upfront for mechanistic plausibility is a significant bet. The second is regulatory, and buyers genuinely need to know it: since 2022 the FDA has taken the position that NMN does not qualify as a dietary supplement because it was previously investigated as a drug, which has already caused major retailers to pull NMN products and leaves the category legally contested. Nothing on this page mentions it. Finally, the absence of any safety warning is the clearest omission. Piperine, the ingredient included deliberately to boost absorption, also raises blood levels of many prescription medicines by inhibiting CYP3A4 and P-glycoprotein; resveratrol and curcumin both affect platelet function; curcumin has been linked to liver injury at supplement doses and aggravates gallstones. If you take any regular medication, speak to a pharmacist before starting this, and ask for the servings count and the piperine amount before committing to a year. Rating: 3.1/5.

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