Endurance Products Company

Free shipping applies on orders over $75, and subscription orders include free shipping regardless of value alongside a 10% discount. Rates for smaller one-time orders are not published on the listing. Since a 200-tablet bottle is $49.99, a single bottle falls below the threshold unless you subscribe.

A 100% satisfaction guarantee is referenced and linked, though the wording is not reproduced on the product page. The company is genuinely contactable, with a phone line on 1-800-483-2532 staffed Monday to Friday 8am to 4pm Pacific, a fax number and a postal address at P.O. Box 3810, Tualatin, Oregon. No email address is published and the on-page chat link points to a placeholder, so the phone is the practical route. Confirm the return window and whether opened bottles are accepted before ordering.

It is nicotinic acid in a vegetable wax matrix releasing over six to eight hours, and the distinction is important. Nicotinic acid is the form with lipid activity; niacinamide has none, and inositol hexanicotinate, marketed as no-flush niacin, releases very little free nicotinic acid and is largely ineffective for cholesterol. On release profile, immediate-release niacin causes pronounced flushing while older polymer-based sustained-release products were associated with greater liver risk, so an intermediate wax matrix profile is specifically designed to balance the two. The brand cites the systematic review that examines this formulation, which is appropriate rather than generic.

The page cites two real papers in full: Dunatchik and colleagues' 2012 systematic review of the wax-matrix formulation in the Journal of Clinical Lipidology, and Sahebkar's 2014 meta-analysis on niacin and endothelial function in Vascular Medicine. Both are genuine and relevant to formulation safety and vascular function markers. What the page does not convey is that the broader clinical picture has shifted: two large trials examining niacin added to statin therapy failed to demonstrate cardiovascular benefit, and one reported increased adverse events including new diabetes, infection and bleeding, which is why major guidelines have largely moved away from niacin for cardiovascular risk reduction. Discuss this with your doctor rather than relying on the page alone.

Gradually, and the availability of three strengths exists precisely for that reason. Niacin causes flushing, itching and skin warmth, which the page acknowledges, and tolerance builds over a few weeks, so starting at 250 mg and working up is far more comfortable than beginning at 750 mg. Take it with food, avoid hot drinks and alcohol around the dose, and do not exceed one tablet daily without a physician's advice, as the label directs. Note that a single 750 mg daily tablet sits below the 1,000 to 2,000 mg range at which niacin produces meaningful lipid changes, so this should not be expected to match prescription niacin therapy.

The brand's own list is comprehensive and clinically correct, and it should be followed. Seek a physician's advice first if you drink more than modest amounts of alcohol, or have poorly controlled diabetes, liver disease, gout, active peptic ulcer disease or unstable angina. It is not recommended during pregnancy or nursing. Those cautions exist for sound reasons: niacin raises blood glucose and can worsen diabetic control, raises uric acid and can precipitate gout, carries hepatotoxic potential at higher doses, and can aggravate ulcers, while alcohol compounds both liver risk and flushing. If you take a statin, a blood pressure medication or an anticoagulant, raise it with your doctor, and expect liver function, glucose and uric acid to be monitored.

The inactive ingredients are fully published as vegetable wax from rice bran and/or carnauba, vegetable stearic acid, vegetable magnesium stearate and silica, all plant-derived. The product is stated as gluten, dairy, sugar and soy free, vegan and vegetarian, preservative-free, third-party tested, and free of the major allergens, which are named individually as milk, egg, fish, shellfish, soy, peanuts and wheat. Manufacturing is in Oregon at an FDA-registered facility stated to meet or exceed cGMP standards.

Every Endurance Products Company code listed on smartstorereview is tested against the live checkout before publication and rechecked regularly, with expired codes removed and the last verified date shown beside each offer. The subscription already carries 10% off with free shipping, though its price is not displayed on the listing, so compare it against the $49.99 one-time price plus shipping. If you are new to niacin, consider starting with the 250 mg strength rather than buying 200 of the 750 mg tablets.